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Pragmatic trials are those that are designed to provide information for the practice of clinical trials in real life. They are often described as a focus on the practical aspects of design that include the recruitment and consent process, as well as adherence and the use of standard equipment.
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A practical trial that employs various investigators and participants from diverse geographical locations is the Home Blood Pressure Management study (HBPM). This kind of heterogeneity, which is essential for a pragmatic trial to be valid and reduce bias in results is also essential. However too much heterogeneity could lead to issues with the design of the trial.
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Pragmatic trials seek to replicate real-life situations and attain maximum external validity. They are typically commissioned by policymakers and practitioners to help guide their decisions. They can also be a great method to determine the cause-effect relationship between an intervention and its results. They should, however, not, be used to replace explanatory studies.
The pragmatism concept is controversial, and there are concerns about whether pragmatic trials should replace explanatory trials or complement them. Schwartz and Lellouch1 suggested the distinction between explanatory trials, which validate the validity of a clinical or physiological hypothesis, and pragmatic trials, 무료슬롯 프라그마틱 which guide the policy and practice of. They also proposed a framework called PRECIS for pragmatic trials.2 This tool tried to define the traits of a pragmatic research study which includes the recruitment, design, and delivery of the intervention and follow-up.
There is an encouraging trend in the number of pragmatic trials that have been published. A recent Medline search using the terms pragmatic and naturalistic, restricted to controlled trials that are randomized (RCTs), yielded 34 articles, as shown in red in Figure 2. This is a sign that the health science community is becoming more acquaint to the subject of pragmatism. However, it is important to remember that the majority of these trials were conducted in primary care settings.
